Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration
نویسندگان
چکیده
منابع مشابه
Chloroquine Phosphate Metabolism and Gender-Based Phenotypic Analysis among Healthy Subjects’ Urine Following Oral Administration
The advent of chloroquine promising activity against the COVID-19 is novel and as such, it is imperative to thoroughly understand and determine the rate at which individual body systems handle the drug. Chloroquine a known antimalarial drug belongs to the chemical class of 4-aminoquinolines. The aim of the study was to analyze Chloroquine and its metabolite in biological fluids of healthy subje...
متن کاملClozapine rechallenge following clozapine-induced pericarditis.
To the Editor: There are many reports describing the development of myocarditis and cardiomyopathy following treatment with clozapine. Fewer reports exist about the development of pericarditis, and reports of successful rechallenges with clozapine following the development of pericarditis are particularly rare. We report the case of a patient successfully resumed on clozapine treatment followin...
متن کاملMyocarditis after administration of clozapine.
OBJECTIVE Clozapine is an atypical antpsychotic medication with established efficacy in patients diagnosed of resistant schizophrenia. However, clozapine has multiple side effects. Cardiac complications such as myocarditis and cardiomyopathy have always been related with treatment with clozapine. METHODS A 42 year old Caucasian male, with history of schizophrenia developed a acute myocarditis...
متن کاملDouble-blind comparison of olanzapine versus clozapine in schizophrenic patients clinically eligible for treatment with clozapine.
BACKGROUND The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptic drugs is a major challenge. Clozapine has been one treatment option; however, it is not universally effective and is limited in its use by safety concerns. With the introduction of newer agents, their performance relative to clozapine is of great clinical interest. METHODS The primary obje...
متن کاملInborn errors of sphingolipid metabolism.
I T is my intent to gather together facts pertaming to the lipidoses which might serve to focus on current problems and to call attention to possible therapeutic approaches. The particular lipidoses to be discussed involve the accumulation in tissues of sphingolipids and may be referred to as sphingolipidoses. They may be classified as “inborn errors of sphingolipid metabolism” on the basis tha...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2018
ISSN: 1423-0127
DOI: 10.1186/s12929-018-0437-1